DTL (gen)

Denticleless protein homolog là protein ở người được mã hóa bởi gen DTL.

DTL
Mã định danh
Danh pháp	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
ID ngoài	OMIM: 610617 HomoloGene: 32313 GeneCards: DTL
Bản thể gen Chức năng phân tử • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding Thành phần tế bào • trung thể • Màng nhân • membrane • nhiễm sắc thể • microtubule organizing center • Hạch nhân • Cul4A-RING E3 ubiquitin ligase complex • Cul4B-RING E3 ubiquitin ligase complex • Bộ xương tế bào • nhân tế bào • Chất nhân • tế bào chất • cytosol • Cul4-RING E3 ubiquitin ligase complex Quá trình sinh học • ubiquitin-dependent protein catabolic process • protein polyubiquitination • protein monoubiquitination • regulation of cell cycle • Quá trình tự nhân đôi ADN • protein ubiquitination • response to UV • translesion synthesis • post-translational protein modification • cellular response to DNA damage stimulus • positive regulation of G2/M transition of mitotic cell cycle • GO:1903364 positive regulation of protein catabolic process • mitotic G2 DNA damage checkpoint signaling • rhythmic process Nguồn: Amigo / QuickGO
Gen cùng nguồn
Loài	Người	Chuột
Entrez	51514	n/a
Ensembl	ENSG00000143476	n/a
UniProt	Q9NZJ0	n/a
RefSeq (mRNA)	NM_001286229 NM_001286230 NM_016448	n/a
RefSeq (protein)	NP_001273158 NP_001273159 NP_057532	n/a
Vị trí gen (UCSC)	n/a	n/a
PubMed		n/a
Wikidata
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Tương tác

DTL có khả năng tương tác với P21.

Đọc thêm

• Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). “L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes”. Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
• Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). “L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage”. Cell Cycle. 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.
• Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). “A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1”. Mol. Cell. 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). “A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). “CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation”. Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
• Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). “DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint”. Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.
• Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). “Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma”. Cell Cycle. 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.