Manchester United, aslà amột Premierđại Leaguediện clubđến involvedtừ Premier League intham thedự [[2016–17 UEFA Europa League 2016–17]], starteddo thevậy competitioncâu inlạc thebộ thirdbóng roundđá wherenày theybắt weređầu drawntừ awayvòng at3 [[EFLvà League One]] teamgặp [[Northampton Town F.C.|Northampton Town]]. AtTại [[SixfieldsSân Stadiumvận động Sixfields]] Manchester United wongiành chiến thắng với tỷ số 3–1 withvới các bàn goalsthắng fromcủa [[Michael Carrick]], [[Ander Herrera]] andvà [[Marcus Rashford]].<ref>{{cite web|last=McNulty |first=Phil |url=http://www.bbc.co.uk/sport/football/37357878 |title=Northampton Town 1–3 Manchester United |publisher=BBC Sport |date=21 September 2016 |accessdate=27 January 2017}}</ref> In the fourth round they were drawn against [[Manchester derby|Manchester]] rivals [[Manchester City F.C.|Manchester City]] at home. At [[Old Trafford]], Manchester United won 1–0 due to a goal from [[Juan Mata]].<ref>{{cite web|last=Reddy |first=Luke |url=http://www.bbc.co.uk/sport/football/37700029 |title=Manchester United 1–0 Manchester City |publisher=BBC Sport |date=27 October 2016 |accessdate=27 January 2017}}</ref> In the quarter-final they drew fellow Premier League team [[West Ham United F.C.|West Ham United]] at Old Trafford, where they progressed 4–1 due to two goals each from [[Zlatan Ibrahimović]] and [[Anthony Martial]] despite manager [[José Mourinho]] serving a touchline ban.<ref>{{cite web|last=Jurejko |first=Jonathan |url=http://www.bbc.co.uk/sport/football/38073805 |title=Manchester United 4–1 West Ham United |publisher=BBC Sport |date=30 November 2016 |accessdate=27 January 2017}}</ref>
In the two legged semi-final, they drew fellow Premier League [[Hull City A.F.C.|Hull City]]. Manchester United won the first leg at Old Trafford 2–0 due to goals from Mata and [[Marouane Fellaini]]<ref>{{cite web|last=Rose |first=Gary |url=http://www.bbc.co.uk/sport/football/38493198 |title=Manchester United 2–0 Hull City |publisher=BBC Sport |date=10 January 2017 |accessdate=27 January 2017}}</ref> and lost the second leg 2–1 at the [[KCOM Stadium]] despite a [[Paul Pogba]] goal but progressed to the final 3–2 on aggregate.<ref>{{cite web|last=Reddy |first=Luke |url=http://www.bbc.co.uk/sport/football/38672990 |title=Hull City 2–1 Manchester United (Agg: 2–3) |publisher=BBC Sport |date=26 January 2017|accessdate=27 January 2017}}</ref>