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| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| verifiedrevid = 456689729
}}{{Chất lượng kém/nguồn|ngày=07|tháng=02|năm=2020|lý do=bản dịch chất lượng kém + một nùi chú thích đỏ}}'''Amlexanox''' (tên thương mại '''Aphthasol''') là một [[Thuốc chống viêm|chất]] điều hòa miễn dịch [[Chống dị ứng|chống]] [[Thuốc chống viêm|viêm]] được sử dụng để điều trị [[Nhiệt miệng|loét]] miệng tái phát (loét canker) và (ở Nhật Bản) một số [[Viêm|tình trạng viêm]]. Thuốc này đã bị ngưng sử dụng ở Mỹ <ref>{{Chú thích web|url=http://www.childrensdmc.org/HealthLibrary/default.aspx?sid=1&pTitle=&ContentTypeID=26&ContentID=665&pTitle=Drug&alpha=A&AdditionalTitle=Aphthasol%C2%AE|title=Amlexanox (Aphthasol®)|access-date=20 November 2013}}</ref>
== Sử dụng trong y tế ==
Tại Nhật Bản, nó được sử dụng để điều trị [[hen phế quản]], [[viêm mũi]] dị [[Viêm mũi|ứng]] và [[Viêm mũi|viêm]] [[Đau mắt đỏ|kết mạc]].<ref name="bell_2005"><cite class="citation journal">Bell J (2005). [http://www.medscape.com/viewarticle/512792 "Amlexanox for the treatment of recurrent aphthous ulcers"]. ''Clin Drug Investig''. '''25''' (9): 555–66. [[Digital object identifier|doi]]:[[doi:10.2165/00044011-200525090-00001|10.2165/00044011-200525090-00001]]. [[PubMed Identifier|PMID]] [//www.ncbi.nlm.nih.gov/pubmed/17532700 17532700].</cite><templatestyles src="Module:Citation/CS1/styles.css"></templatestyles></ref>
== Chống chỉ định ==
Thuốc chống chỉ định ở những người bị dị ứng đã biết với nó.<ref name="medline_2009"><cite class="citation web">[https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601017.html "Amlexanox"]. ''MedlinePlus''. U.S. National Library of Medicine. February 2009<span class="reference-accessdate">. Retrieved <span class="nowrap">12 February</span> 2013</span>.</cite><templatestyles src="Module:Citation/CS1/styles.css"></templatestyles></ref>
== Tác dụng phụ ==
Amlexanox có thể gây cảm giác đau nhói hoặc đau rát, buồn nôn hoặc tiêu chảy.<ref name="medline_2009"><cite class="citation web">[https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601017.html "Amlexanox"]. ''MedlinePlus''. U.S. National Library of Medicine. February 2009<span class="reference-accessdate">. Retrieved <span class="nowrap">12 February</span> 2013</span>.</cite><templatestyles src="Module:Citation/CS1/styles.css"></templatestyles></ref>
== Cơ chế hoạt động ==
Thuốc là một chất [[Thuốc chống viêm|chống viêm]], [[Liệu pháp miễn dịch|điều hòa miễn dịch]] <ref name="bell_2005"><cite class="citation journal">Bell J (2005). [http://www.medscape.com/viewarticle/512792 "Amlexanox for the treatment of recurrent aphthous ulcers"]. ''Clin Drug Investig''. '''25''' (9): 555–66. [[Digital object identifier|doi]]:[[doi:10.2165/00044011-200525090-00001|10.2165/00044011-200525090-00001]]. [[PubMed Identifier|PMID]] [//www.ncbi.nlm.nih.gov/pubmed/17532700 17532700].</cite><templatestyles src="Module:Citation/CS1/styles.css"></templatestyles></ref> [[chống dị ứng]] <ref name="mesh_2009"><cite class="citation web">[https://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=amlexanox "Amlexanox"]. ''MeSH''. U.S. National Library of Medicine. 2009<span class="reference-accessdate">. Retrieved <span class="nowrap">12 February</span> 2013</span>.</cite><templatestyles src="Module:Citation/CS1/styles.css"></templatestyles></ref>.<ref name="elad_2011"><cite class="citation journal">Elad S, Epstein JB, von Bültzingslöwen I, Drucker S, Tzach R, Yarom N (March 2011). "Topical immunomodulators for management of oral mucosal conditions, a systematic review; Part II: miscellaneous agents". ''Expert Opin Emerg Drugs''. '''16''' (1): 183–202. [[Digital object identifier|doi]]:[[doi:10.1517/14728214.2011.528390|10.1517/14728214.2011.528390]]. [[PubMed Identifier|PMID]] [//www.ncbi.nlm.nih.gov/pubmed/21244328 21244328].</cite><templatestyles src="Module:Citation/CS1/styles.css"></templatestyles></ref>
== Tổng hợp ==
[[Tập tin:Amlexanoxsynthesis.png|giữa|nhỏ|600x600px| Tổng hợp amlexanox:<ref>{{Chú thích tạp chí|last=Nohara|first=A.|last2=Ishiguro|first2=T.|last3=Ukawa|first3=K.|last4=Sugihara|first4=H.|last5=Maki|first5=Y.|last6=Sanno|first6=Y.|year=1985|title=<nowiki>Studies on Antianaphylactic Agents. 7. Synthesis of Antiallergic 5-Oxo-5H-\1]benzopyrano\2,3-b]pyridines</nowiki>|journal=Journal of Medicinal Chemistry|volume=28|issue=5|pages=559–68|doi=10.1021/jm50001a005|pmc=|pmid=3989816}}</ref>]]
==Chú thích==
== Tham{{tham khảo ==}}
{{Tham khảo|35em|refs=<ref name=gonsalves_2007>{{cite journal |vauthors=Gonsalves WC, Chi AC, Neville BW | title = Common oral lesions: Part I. Superficial mucosal lesions | journal = Am Fam Physician | volume = 75 | issue = 4 | pages = 501–7 | date = February 2007 | pmid = 17323710 | doi = | url = http://www.aafp.org/afp/2007/0215/p501.html }}</ref>
<ref name=medline_2009>{{cite web |url=https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601017.html |title=Amlexanox |date=February 2009 |work=MedlinePlus |publisher=U.S. National Library of Medicine |accessdate=12 February 2013}}</ref>
<ref name=medscape_aphthous_2012>{{cite web | author = Plewa MC | title=Pediatric Aphthous Ulcers Treatment & Management |date=March 2012 |work=Medscape Reference|publisher=Medscape |accessdate=14 February 2013 |url=http://emedicine.medscape.com/article/909213-treatment}}</ref>
<ref name=pubchem>{{cite web |url=https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?q=all&cid=2161#ec |title=Amlexanox |work=PubChem |publisher=U.S. National Library of Medicine |accessdate=12 February 2013}}</ref>
<ref name=bailey_2011>{{cite journal |vauthors=Bailey J, McCarthy C, Smith RF | title = Clinical inquiry. What is the most effective way to treat recurrent canker sores? | journal = J Fam Pract | volume = 60 | issue = 10 | pages = 621–32 | date = October 2011 | pmid = 21977491 | doi = | url = http://www.jfponline.com/Pages.asp?AID=9930 }}</ref>
<ref name=medscape_behcet_2012>{{cite web |vauthors=Yousefi M, Ferringer T, Lee S, Bang D | title=Dermatologic Aspects of Behcet Disease Treatment & Management |date=July 2012 |work=Medscape Reference|publisher=Medscape |accessdate=14 February 2013 |url=http://emedicine.medscape.com/article/1122381-treatment}}</ref>
<ref name=bell_2005>{{cite journal | author = Bell J | title = Amlexanox for the treatment of recurrent aphthous ulcers | journal = Clin Drug Investig | volume = 25 | issue = 9 | pages = 555–66 | year = 2005 | pmid = 17532700 | doi = 10.2165/00044011-200525090-00001| url = http://www.medscape.com/viewarticle/512792 }}</ref>
<ref name=mesh_2009>{{cite web |url=https://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=amlexanox |title=Amlexanox |date=2009 |work=MeSH |publisher=U.S. National Library of Medicine |accessdate=12 February 2013}}</ref>
<ref name=elad_2011>{{cite journal |vauthors=Elad S, Epstein JB, von Bültzingslöwen I, Drucker S, Tzach R, Yarom N | title = Topical immunomodulators for management of oral mucosal conditions, a systematic review; Part II: miscellaneous agents | journal = Expert Opin Emerg Drugs | volume = 16 | issue = 1 | pages = 183–202 | date = March 2011 | pmid = 21244328 | doi = 10.1517/14728214.2011.528390 }}</ref>
<ref name=reilly_2013>{{cite journal |vauthors=Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR | title = An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice | journal = Nat. Med. | volume = 19| issue = 3| pages = 313–21| date = February 2013 | pmid = 23396211 | doi = 10.1038/nm.3082 | pmc=3594079}}</ref>
<ref name=patent>{{cite patent |country=US |number=5362737 |status=patent |title=Methods of treating aphthous ulcers and other mucocutaneous disorders with amlexanox |pubdate= |date= November 8, 1994 |inventor=Kakubhai R. Vora, Atul Khandwala, Charles G. Smith |assign1=Chemex Pharmaceuticals, Inc.}}</ref>
<ref name=burgess_2008>{{cite journal |vauthors=Burgess JA, van der Ven PF, Martin M, Sherman J, Haley J | title = Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract | journal = J Contemp Dent Pract | volume = 9 | issue = 3 | pages = 88–98 | year = 2008 | pmid = 18335124 | doi = | url = }}</ref>
<ref name=kuteyi_2012>{{cite journal | author = Kuteyi T, Okwundu CI | title = Topical treatments for HIV-related oral ulcers | journal = Cochrane Database Syst Rev | volume = 1 | issue = | pages = CD007975 | year = 2012 | pmid = 22258979 | doi = 10.1002/14651858.CD007975.pub2 | editor1-last = Kuteyi | editor1-first = Teslim }}</ref>
<ref name=Chiang>{{cite journal |vauthors=Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR | title = The protein kinase IKKepsilon regulates energy balance in obese mice | journal = Cell | volume = 138 | issue = 5 | pages = 961–75 | date = September 2009 | pmid = 19737522 | pmc = 2756060 | doi = 10.1016/j.cell.2009.06.046 }}</ref>}}
[[Thể loại:Axit cacboxylic]]
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