{{OneLegResult|[[:en:FC Istiklol|Istiklol]]|TJK|[[2021 AFC Champions League knockout stage#R16 West 1|0-1]]|'''[[:en:Persepolis F.C.|Persepolis]]'''|IRN}}
{{OneLegResult|[[:en:Sharjah FC|Sharjah]]|UAE|[[2021 AFC Champions League knockout stage#R16 West 2|1-1]] {{aet}}<br>{{pso|4-5}}|'''[[:en:Al Wahda FC (UAE)|Al-Wahda]]'''|UAE}}
{{OneLegResult|[[:en:Esteghlal F.C.|Esteghlal]]|IRN|[[2021 AFC Champions League knockout stage#R16 West 3|0-2]]|'''[[:en:Al Hilal FC|Al Hilal]]'''|KSA}}
{{OneLegResult|'''[[:en:Al Nassr FC|Al-Nassr]]'''|KSA|[[2021 AFC Champions League knockout stage#R16 West 4|1-0]]|[[:en:Tractor S.C.|Tractor]]|IRN}}
|}
{{OneLegStart}}
|+Phía Đông
{{OneLegResult|'''[[:en:Ulsan Hyundai FC|Ulsan Hyundai]]'''|KOR|[[2021 AFC Champions League knockout stage#R16 Đông 1|0-0]] {{aet}}<br>{{pso|3–2}}|[[:en:Kawasaki Frontale|Kawasaki Frontale]]|JPN}}
{{OneLegResult|'''[[:en:Nagoya Grampus|Nagoya Grampus]]'''|JPN|[[2021 AFC Champions League knockout stage#R16 Đông 2|4–2]]|[[:en:Daegu FC|Daegu FC]]|KOR}}
{{OneLegResult|[[:en:Jeonbuk Hyundai Motors FC|Jeonbuk Hyundai Motors]]|KOR|[[2021 AFC Champions League knockout stage#R16 Đông 3|{{nowrap|{{small|14–15 th9 (Vòng 16 đội Đông Á 3)}}}}]]|[[Câu lạc bộ bóng đá BG Pathum United|BG Pathum United]]|THA}}
{{OneLegResult|[[:en:Cerezo Osaka|Cerezo Osaka]]|JPN|[[2021 AFC Champions League knockout stage#R16 Đông 4|{{nowrap|{{small|14–15 th9 (Vòng 16 đội Đông Á 4)}}}}]]|[[:en:Pohang Steelers|Pohang Steelers]]|KOR}}
