AZIN2

AZIN2
Mã định danh
Danh pháp	AZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
ID ngoài	OMIM: 608353 HomoloGene: 62172 GeneCards: AZIN2
Bản thể gen
Chức năng phân tử	• putrescine transmembrane transporter activity; • catalytic activity; • GO:0001948, GO:0016582 protein binding; • ornithine decarboxylase activator activity; • arginine decarboxylase activity; • ornithine decarboxylase activity;
Thành phần tế bào	• transport vesicle; • tế bào chất; • Ty thể; • trans-Golgi network; • cell projection; • bộ máy Golgi; • nhân tế bào; • sợi trục; • granular vesicle; • membrane; • sợi nhánh; • perinuclear region of cytoplasm; • cis-Golgi network; • GO:0016023 cytoplasmic vesicle; • soma; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • cytosol;
Quá trình sinh học	• positive regulation of polyamine transmembrane transport; • Sự tạo tinh; • putrescine transport; • ornithine metabolic process; • putrescine biosynthetic process from ornithine; • trans-Golgi network membrane organization; • agmatine biosynthetic process; • GO:0048554 positive regulation of catalytic activity; • polyamine biosynthetic process; • GO:1903363 negative regulation of protein catabolic process;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	113451
	n/a
	ENSG00000142920
	n/a
	Q96A70
	n/a
NM_001293562; NM_001301823; NM_001301824; NM_001301825; NM_001301826;
	NM_052998; NM_001350398; NM_001350399; NM_001350400; NM_001350401; NM_001350402; NM_001376722; NM_001376724; NM_001376725; NM_001376727; NM_001376729; NM_001376730; NM_001376732
	n/a
NP_001280491; NP_001288752; NP_001288753; NP_001288754; NP_001288755;
	NP_443724; NP_001337327; NP_001337328; NP_001337329; NP_001337330; NP_001337331; NP_001363651; NP_001363653; NP_001363654; NP_001363656; NP_001363658; NP_001363659; NP_001363661
	n/a
	Wikidata
Xem/Sửa Người

Chất ức chế antizyme 2 (tiếng Anh: Antizyme inhibitor 2, AzI2), còn được gọi là arginine decarboxylase (ADC) là enzyme ở người được mã hóa bởi gen AZIN2.^[2]^[3]^[4]

Tham khảo sửa

^ “Human PubMed Reference:”.
^ Pitkänen LT, Heiskala M, Andersson LC (2001). “Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes”. Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.
^ Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). “Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine”. Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMID 14738999.
^ “Entrez Gene: ADC arginine decarboxylase”.

Liên kết ngoài sửa

Vị trí bộ gen AZI2 ở người và thông tin chi tiết về gen AZI2 có sẵn trên UCSC Genome Browser.
Vị trí bộ gen AZIN2 ở người và thông tin chi tiết về gen AZIN2 có sẵn trên UCSC Genome Browser.

Đọc thêm sửa

Nagase T, Kikuno R, Ohara O (2001). “Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins”. DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Coleman CS, Hu G, Pegg AE (2004). “Putrescine biosynthesis in mammalian tissues”. Biochem. J. 379 (Pt 3): 849–55. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (2005). “Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity”. Biochem. Biophys. Res. Commun. 328 (1): 206–12. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (2006). “Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity”. J. Biol. Chem. 281 (41): 30896–906. doi:10.1074/jbc.M602840200. PMID 16916800.
Tian H, Liu X, Zhang B, Sun Q, Sun D (2007). “Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth”. Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 423–30. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
Levin VA, Jochec JL, Shantz LM, Aldape KD (2007). “Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy”. Int. J. Cancer. 121 (10): 2279–83. doi:10.1002/ijc.22914. PMID 17582600.
Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (2008). “Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase”. Biochem. J. 409 (1): 187–92. doi:10.1042/BJ20071004. PMID 17900240.

Bài viết về một gen trên nhiễm sắc thể 1 ở người này vẫn còn sơ khai. Bạn có thể giúp Wikipedia mở rộng nội dung để bài được hoàn chỉnh hơn.

[1] “Human PubMed Reference:”.

[pmid11587527-2] Pitkänen LT, Heiskala M, Andersson LC (2001). “Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes”. Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.

[pmid14738999-3] Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). “Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine”. Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMID 14738999.

[entrez-4] “Entrez Gene: ADC arginine decarboxylase”.

[2]

[3]

[4]

[1]