ETV3

Biến thể Ets 3 (tiếng Anh: Ets variant 3) là protein ở người được mã hóa bởi gen ETV3.

ETV3
Mã định danh
Danh pháp	ETV3, METS, PE-1, PE1, bA110J1.4, ETS variant 3, ETS variant transcription factor 3
ID ngoài	OMIM: 164873 HomoloGene: 21085 GeneCards: ETV3
Bản thể gen Chức năng phân tử • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DEAD/H-box RNA helicase binding • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • molecular function • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Thành phần tế bào • RNA polymerase II transcription repressor complex • transcription repressor complex • nhân tế bào Quá trình sinh học • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • biệt hóa tế bào • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • cellular response to granulocyte macrophage colony-stimulating factor stimulus • transcription, DNA-templated • negative regulation of cell population proliferation • GO:0022610 quá trình sinh học Nguồn: Amigo / QuickGO
Gen cùng nguồn
Loài	Người	Chuột
Entrez	2117	n/a
Ensembl	ENSG00000117036	n/a
UniProt	P41162	n/a
RefSeq (mRNA)	NM_001145312 NM_005240	n/a
RefSeq (protein)	NP_001138784 NP_005231	n/a
Vị trí gen (UCSC)	n/a	n/a
PubMed		n/a
Wikidata
Xem/Sửa Người

Đọc thêm

• Klemsz M, Hromas R, Raskind W, Bruno E, Hoffman R (tháng 3 năm 1994). “PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23”. Genomics. 20 (2): 291–4. doi:10.1006/geno.1994.1169. PMID 8020980.
• Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (tháng 7 năm 2007). “Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS”. Cell Cycle. 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
• Anney RJ, Lasky-Su J, O'Dúshláine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vásquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M (tháng 12 năm 2008). “Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study”. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (8): 1369–78. doi:10.1002/ajmg.b.30871. PMID 18951430.
• Sawka-Verhelle D, Escoubet-Lozach L, Fong AL, Hester KD, Herzig S, Lebrun P, Glass CK (tháng 4 năm 2004). “PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation”. The Journal of Biological Chemistry. 279 (17): 17772–84. doi:10.1074/jbc.M311991200. PMID 14754893.
• Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK (tháng 4 năm 2002). “An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation”. Cell. 109 (2): 169–80. doi:10.1016/S0092-8674(02)00714-6. PMID 12007404.
• Mesquita B, Lopes P, Rodrigues A, Pereira D, Afonso M, Leal C, Henrique R, Lind GE, Jerónimo C, Lothe RA, Teixeira MR (tháng 2 năm 2013). “Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes”. Breast Cancer Research and Treatment. 138 (1): 37–45. doi:10.1007/s10549-013-2408-2. PMID 23329352.
• El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray PJ (tháng 12 năm 2007). “Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway”. Journal of Immunology. 179 (11): 7215–9. doi:10.4049/jimmunol.179.11.7215. PMID 18025162.