GNAI3

GNAI3
Cấu trúc được biết đến
PDB	Tìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB
	2IHB, 2ODE, 2V4Z, 4G5O, 4G5R, 4G5S
Mã định danh
Danh pháp	GNAI3, 87U6, ARCND1, G protein subunit alpha i3, HG1A
ID ngoài	OMIM: 139370 HomoloGene: 55975 GeneCards: GNAI3
Mẫu hình biểu hiện RNA
	; ; ; ;
	Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử	• signal transducer activity; • metal ion binding; • protein domain specific binding; • nucleotide binding; • GTPase activating protein binding; • guanyl nucleotide binding; • GDP binding; • G protein-coupled receptor binding; • G-protein beta/gamma-subunit complex binding; • G protein-coupled serotonin receptor binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • GTP binding;
Thành phần tế bào	• extracellular exosome; • lysosomal membrane; • tế bào chất; • microtubule organizing center; • bộ máy Golgi; • heterotrimeric G-protein complex; • membrane; • trung thể; • midbody; • membrane raft; • zymogen granule; • Bộ xương tế bào; • Màng tế bào; • nhân tế bào; • Hạch nhân; • Golgi membrane; • endoplasmic reticulum membrane;
Quá trình sinh học	• chu kỳ tế bào; • GO:0072468 signal transduction; • negative regulation of adenylate cyclase activity; • GTP metabolic process; • Phân bào; • vesicle fusion; • dopamine receptor signaling pathway; • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • Cuộn gập protein; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • GO:0015915 transport; • positive regulation of macroautophagy; • G protein-coupled receptor signaling pathway; • brain development; • positive regulation of superoxide anion generation; • positive regulation of NAD(P)H oxidase activity; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of apoptotic signaling pathway;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	2773
	n/a
	ENSG00000065135
	n/a
	P08754
	n/a
	NM_006496
	n/a
	NP_006487
	n/a
	Wikidata
Xem/Sửa Người

Protein liên kết nucleotide guanine G(k), tiểu đơn vị alpha (tiếng Anh: Guanine nucleotide-binding protein G(k) subunit alpha) là protein ở người được mã hóa bởi gen GNAI3.^[2]^[3]

Tương tác sửa

GNAI3 có khả năng tương tác với:

Xem thêm sửa

Tiểu đơn vị alpha Gi

Tham khảo sửa

^ “Human PubMed Reference:”.
^ Didsbury JR, Snyderman R (tháng 7 năm 1987). “Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families”. FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953.
^ “Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3”.
^ Hunt TW, Fields TA, Casey PJ, Peralta EG (tháng 9 năm 1996). “RGS10 is a selective activator of G alpha i GTPase activity”. Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.
^ ^a ^b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (tháng 8 năm 2001). “RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
^ ^a ^b Chen C, Zheng B, Han J, Lin SC (tháng 3 năm 1997). “Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. The Journal of Biological Chemistry. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
^ Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (tháng 3 năm 1999). “Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes”. Journal of Immunology. 162 (5): 2677–82. PMID 10072511.
^ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (tháng 10 năm 2001). “RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
^ Gagnon AW, Murray DL, Leadley RJ (tháng 7 năm 2002). “Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cellular Signalling. 14 (7): 595–606. doi:10.1016/s0898-6568(02)00012-8. PMID 11955952.
^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (tháng 12 năm 1996). “GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
^ Woulfe DS, Stadel JM (tháng 6 năm 1999). “Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
^ De Vries L, Mousli M, Wurmser A, Farquhar MG (tháng 12 năm 1995). “GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain”. Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
^ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (tháng 2 năm 2001). “Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sciences. 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID 11253162.
^ Tall GG, Krumins AM, Gilman AG (tháng 3 năm 2003). “Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
^ Lee MJ, Evans M, Hla T (tháng 5 năm 1996). “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Đọc thêm sửa

Downes GB, Gautam N (tháng 12 năm 1999). “The G protein subunit gene families”. Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
Sidhu A, Niznik HB (tháng 11 năm 2000). “Coupling of dopamine receptor subtypes to multiple and diverse G proteins”. International Journal of Developmental Neuroscience. 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID 10978845.
Jiang M, Pandey S, Tran VT, Fong HK (tháng 5 năm 1991). “Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells”. Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3907–11. doi:10.1073/pnas.88.9.3907. PMC 51562. PMID 1902575.
Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildebrandt JD, Iyengar R (tháng 4 năm 1990). “Distinct guanine nucleotide binding and release properties of the three Gi proteins”. The Journal of Biological Chemistry. 265 (11): 6268–73. PMID 2108158.
Suki WN, Abramowitz J, Mattera R, Codina J, Birnbaumer L (tháng 8 năm 1987). “The human genome encodes at least three non-allellic G proteins with alpha i-type subunits”. FEBS Letters. 220 (1): 187–92. doi:10.1016/0014-5793(87)80900-6. PMID 2440724.
Codina J, Olate J, Abramowitz J, Mattera R, Cook RG, Birnbaumer L (tháng 5 năm 1988). “Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels”. The Journal of Biological Chemistry. 263 (14): 6746–50. PMID 2452165.
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y (tháng 5 năm 1988). “Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs”. The Journal of Biological Chemistry. 263 (14): 6656–64. PMID 2834384.
Beals CR, Wilson CB, Perlmutter RM (tháng 11 năm 1987). “A small multigene family encodes Gi signal-transduction proteins”. Proceedings of the National Academy of Sciences of the United States of America. 84 (22): 7886–90. doi:10.1073/pnas.84.22.7886. PMC 299440. PMID 3120178.
Kim SY, Ang SL, Bloch DB, Bloch KD, Kawahara Y, Tolman C, Lee R, Seidman JG, Neer EJ (tháng 6 năm 1988). “Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines”. Proceedings of the National Academy of Sciences of the United States of America. 85 (12): 4153–7. doi:10.1073/pnas.85.12.4153. PMC 280384. PMID 3132707.
Migeon JC, Thomas SL, Nathanson NM (tháng 7 năm 1995). “Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits”. The Journal of Biological Chemistry. 270 (27): 16070–4. doi:10.1074/jbc.270.27.16070. PMID 7608168.
Raymond JR, Olsen CL, Gettys TW (tháng 10 năm 1993). “Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha”. Biochemistry. 32 (41): 11064–73. doi:10.1021/bi00092a016. PMID 8218170.
Wu D, LaRosa GJ, Simon MI (tháng 7 năm 1993). “G protein-coupled signal transduction pathways for interleukin-8”. Science. 261 (5117): 101–3. doi:10.1126/science.8316840. PMID 8316840.
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (tháng 6 năm 1993). “Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy”. Endocrinology. 132 (6): 2484–90. doi:10.1210/en.132.6.2484. PMID 8504751.
De Vries L, Mousli M, Wurmser A, Farquhar MG (tháng 12 năm 1995). “GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain”. Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (tháng 1 năm 1996). “The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families”. Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
Lee MJ, Evans M, Hla T (tháng 5 năm 1996). “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.
Solomon KR, Rudd CE, Finberg RW (tháng 6 năm 1996). “The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes”. Proceedings of the National Academy of Sciences of the United States of America. 93 (12): 6053–8. doi:10.1073/pnas.93.12.6053. PMC 39187. PMID 8650218.
Zhang J, Pratt RE (tháng 6 năm 1996). “The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus”. The Journal of Biological Chemistry. 271 (25): 15026–33. doi:10.1074/jbc.271.25.15026. PMID 8663053.
Hunt TW, Fields TA, Casey PJ, Peralta EG (tháng 9 năm 1996). “RGS10 is a selective activator of G alpha i GTPase activity”. Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.

Bản mẫu:Peptide và protein tín hiệu nội bào Bản mẫu:GTPase

[1] “Human PubMed Reference:”.

[pmid3109953-2] Didsbury JR, Snyderman R (tháng 7 năm 1987). “Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families”. FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953.

[entrez-3] “Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3”.

[pmid8774883-4] Hunt TW, Fields TA, Casey PJ, Peralta EG (tháng 9 năm 1996). “RGS10 is a selective activator of G alpha i GTPase activity”. Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.

[pmid11387333-5] Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (tháng 8 năm 2001). “RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.

[pmid9079700-6] Chen C, Zheng B, Han J, Lin SC (tháng 3 năm 1997). “Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. The Journal of Biological Chemistry. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.

[pmid10072511-7] Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (tháng 3 năm 1999). “Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes”. Journal of Immunology. 162 (5): 2677–82. PMID 10072511.

[pmid11563974-8] Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (tháng 10 năm 2001). “RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes”. The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.

[pmid11955952-9] Gagnon AW, Murray DL, Leadley RJ (tháng 7 năm 2002). “Cloning and characterization of a novel regulator of G protein signalling in human platelets”. Cellular Signalling. 14 (7): 595–606. doi:10.1016/s0898-6568(02)00012-8. PMID 11955952.

[pmid8986788-10] De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (tháng 12 năm 1996). “GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.

[pmid10364213-11] Woulfe DS, Stadel JM (tháng 6 năm 1999). “Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.

[pmid8524874-12] De Vries L, Mousli M, Wurmser A, Farquhar MG (tháng 12 năm 1995). “GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain”. Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.

[pmid11253162-13] Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (tháng 2 năm 2001). “Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sciences. 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID 11253162.

[pmid12509430-14] Tall GG, Krumins AM, Gilman AG (tháng 3 năm 2003). “Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.

[pmid8626678-15] Lee MJ, Evans M, Hla T (tháng 5 năm 1996). “The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

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